ELF3 antibody (10R-1244)

Mouse monoclonal ELF3 antibody

Synonyms Monoclonal ELF3 antibody, Anti-ELF3 antibody, E74-like factor 3 antibody, ESE-1 antibody, ELF 3 antibody, ELF 3, ELF-3, ELF-3 antibody, ESX antibody, EPR-1 antibody, ERT antibody, ELF3
Specificity Human ELF3
Cross Reactivity Human. Other species not studied
Applications Dot Blot
Immunogen ELF3 antibody was raised in mouse using recombinant E74-Like Factor 3 (Ets Domain Transcription Factor,Epithelial-Specific ) (Elf3)

Images

Western Blot analysis of immunized recombinant protein using ELF3 antibody (10R-1244)

Specifications

Host Mouse
Clone ELF3B10C4
Isotype IgG1
Method of Purification ELF3 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer ELF3 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance ELF3 is a transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.

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Images

  • Western Blot analysis of immunized recombinant protein using ELF3 antibody (10R-1244)

Availability: In stock

Price: $190.00
Size: 50 ug
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