ELK1 antibody (10R-1942)

Mouse monoclonal ELK1 antibody

Synonyms Monoclonal ELK1 antibody, Anti-ELK1 antibody, ELK-1 antibody, ELK1, ELK 1, ELK-1, ELK-1 antibody, ELK 1 antibody, ELK 1 antibody
Cross Reactivity Human
Applications ELISA, IHC, WB
Immunogen ELK1 antibody was raised in Mouse using a purified recombinant fragment of ELK1 expressed in E. coli as the immunogen.

Images

Immunohistochemical staining using ELK1 antibody (10R-1942)

Immunohistochemical analysis of paraffin-embedded human brain tumor tissue, showing nuclear and cytoplasmic localization using ELK1 antibody with DAB staining.

Specifications

Host Mouse
Clone 3H6D12/4H9C8/4H9F1
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily,which is located on chromosome Xp11. 2 and stimulates transcription. binds to purine-rich DNA sequences. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus, It appears to be a direct target of activated MAP kinase.

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Images

  • Immunohistochemical staining using ELK1 antibody (10R-1942) | Immunohistochemical analysis of paraffin-embedded human brain tumor tissue, showing nuclear and cytoplasmic localization using ELK1 antibody with DAB staining.
  • Western Blot analysis using ELK1 antibody (10R-1942) | Western Blot showing ELK1 antibody used against truncated ELK1 recombinant protein (1) and K562 cell lysate (2).

Availability: In stock

Price: $425.00
Size: 100 ul
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