EP300 antibody (10R-2005)
Mouse monoclonal EP300 antibody
|Synonyms||Monoclonal EP300 antibody, Anti-EP300 antibody, EP 300 antibody, EP-300, p300 antibody, EP 300, E1A binding protein p300 antibody, EP-300 antibody, EP300|
|Immunogen||EP300 antibody was raised in Mouse using a purified recombinant fragment of EP300 expressed in E. coli as the immunogen.|
Western Blot analysis using EP300 antibody (10R-2005)
Western Blot showing EP300 antibody used against truncated EP300-His recombinant protein (1).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CBP (CREB-binding protein), and like CBP can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.|
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