EpCAM antibody (10R-2381)

Mouse monoclonal EpCAM antibody

Synonyms Monoclonal EpCAM antibody, Anti-EpCAM antibody, Ep-CAM antibody, Epithelial Specific Antigen antibody
Cross Reactivity To be determined by the end user
Applications IF, IHC, WB
Immunogen EpCAM antibody was raised in mouse using HT-29 colon carcinoma cell line as the immunogen.

Specifications

Host Mouse
Clone HEA125
Isotype IgG1
Method of Purification EpCAM antibody was purified by Protein A affinity chromatography
Form & Buffer Supplied in liquid form, contains 0.09% NaN3 and 0.5% BSA in PBS pH 7.4

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Store at 2-8 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance EpCAM is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signalling and polarity. It has been used as an immunotherapeutic target in the treatment of gastrointestinal, urological and other carcinomas. It is expressed in undifferentiated pluripotent stem cells.

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