ERBB3 antibody (10R-1816)

Mouse monoclonal ERBB3 antibody

Synonyms Monoclonal ERBB3 antibody, Anti-ERBB3 antibody, ERBB-3 antibody, ERBB 3 antibody, ERBB3, ERBB 3, ERBB-3, ERBB 3 antibody, ERBB-3 antibody
Cross Reactivity Human
Applications ELISA, IF, WB
Immunogen ERBB3 antibody was raised in Mouse using purified recombinant extracellular fragment of human ERBB3 (aa22-369) fused with hIgGFc tag expressed in HEK293 cells as the immunogen.

Images

Immunofluorescent staining using Western Blot analysis using ERBB3 antibody (10R-1816) (ERBB3 antibody)

Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular ERBB3 (aa22-369)-hIgGFc using ERBB3 antibody (green). Blue: DRAQ5 fluorescent DNA dye.

Specifications

Host Mouse
Clone 2F9
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IF: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Receptor tyrosine-protein kinase ERBB-3 is an enzyme that in humans is encoded by the ERBB3 gene. The ERBB3 membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.

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Images

  • Immunofluorescent staining using Western Blot analysis using ERBB3 antibody (10R-1816) (ERBB3 antibody) | Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular ERBB3 (aa22-369)-hIgGFc using ERBB3 antibody (green). Blue: DRAQ5 fluorescent DNA dye.
  • Western Blot analysis using ERBB3 antibody (10R-1816) | Western Blot showing ERBB3 antibody used against human ERBB3 (aa22-369)-hIgGFc trasfected HEK293 cell lysate (1).

Availability: In stock

Price: $345.00
Size: 100 ul
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