ERBB3 antibody (10R-1998)

Mouse monoclonal ERBB3 antibody

Synonyms Monoclonal ERBB3 antibody, Anti-ERBB3 antibody, Erythroblastic leukemia viral oncogene homolog 3 antibody, ERBB 3 antibody, V-erb-b2 antibody, ERBB 3, ERBB3, ERBB-3, ERBB-3 antibody
Cross Reactivity Human
Applications ELISA, IHC, WB
Immunogen ERBB3 antibody was raised in Mouse using a purified recombinant fragment of ERBB3(aa1175-1275) expressed in E. coli as the immunogen.

Images

Immunohistochemical staining using ERBB3 antibody (10R-1998)

Immunohistochemical analysis of paraffin-embedded human cerebra (left) and breast carcinoma tissue (right),showing cytoplasmic and membrane location with DAB staining using ERBB3 antibody.

Specifications

Host Mouse
Clone 3F10F6
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance ERBB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.

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Images

  • Immunohistochemical staining using ERBB3 antibody (10R-1998) | Immunohistochemical analysis of paraffin-embedded human cerebra (left) and breast carcinoma tissue (right),showing cytoplasmic and membrane location with DAB staining using ERBB3 antibody.
  • Western Blot analysis using ERBB3 antibody (10R-1998) | Western Blot showing ERBB3 antibody used against truncated Trx-ERBB3 recombinant protein (1) and MBP-ERBB3 (aa1175-1275) recombinant protein (2).

Availability: In stock

Price: $345.00
Size: 100 ul
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