ERBB3 antibody (10R-1999)
Mouse monoclonal ERBB3 antibody
|Synonyms||Monoclonal ERBB3 antibody, Anti-ERBB3 antibody, V-erb-b2 antibody, ERBB-3, ERBB-3 antibody, Erythroblastic leukemia viral oncogene homolog 3 antibody, ERBB3, ERBB 3 antibody, ERBB 3|
|Immunogen||ERBB3 antibody was raised in Mouse using a purified recombinant fragment of ERBB3(aa1175-1275) expressed in E. coli as the immunogen.|
Western Blot analysis using ERBB3 antibody (10R-1999)
Western Blot showing ERBB3 antibody used against truncated Trx-ERBB3 recombinant protein (1), MBP-ERBB3 (aa1175-1275) recombinant protein (2) and truncated ERBB3 (aa665-1342)-hIgGFc transfected CH0-K1 cell lysate (3).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||ERBB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.|
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