Erk1/2 antibody (10R-8461)

Mouse monoclonal Erk1/2 antibody

Synonyms Monoclonal Erk1/2 antibody, Anti-Erk1/2 antibody, MAPK3 antibody, mitogen-activated protein kinase 3 antibody, BOS_22892 antibody, Erk-1 antibody, ERK1 antibody, Ert2 antibody, Esrk1 antibody, extracellular signal-regulated kinase 1 antibody, extracellular signal-regulated kinase-1 antibody, extracellular signal-related kinase 1 antibody, fi06b09 antibody, HS44KDAP antibody, HUMKER1A antibody, insulin-stimulated MAP2 kinase antibody, MAPK1 antibody, MAPK 1 antibody, MAPK 3 antibody, MAP kinase 1 antibody, MAP kinase 3 antibody, MAP kinase-activated protein kinase 3 antibody, MAP kinase isoform p44 antibody, microtubule-associated protein 2 kinase antibody, mitogen-activated 3 (MAP kinase 3 antibody, mitogen-activated protein kinase 1 antibody, mitogen activated protein kinase 3 antibody, mitogen-activated protein kinase 3-like antibody, MNK1 antibody, Mtap2k antibody, p44 antibody, p44) antibody, p44erk1 antibody, p44-ERK1 antibody, p44mapk antibody, p44-MAPK antibody, p44 MAP kinase antibody, pp42/MAP kinase antibody, PRKM3 antibody, zERK1 antibody
Cross Reactivity Human, Mouse, Rat
Applications ELISA, WB
Immunogen Erk1/2 antibody was raised in Mouse using a His-tagged recombinant human ERK1 protein purified from E.coli as the immunogen

Images

Western Blot analysis using Erk1/2 antibody (10R-8461)

Specifications

Host Mouse
Clone 3A1
Isotype IgG1 kappa
Method of Purification Erk1/2 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1: 2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase, and activates it as well. Once actived, Raf phosphorylates other two kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in ERK 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1.

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Images

  • Western Blot analysis using Erk1/2 antibody (10R-8461) |

Availability: In stock

Price: $295.00
Size: 100 ul
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