Erk1 antibody (10R-8498)

Mouse monoclonal Erk1 antibody

Synonyms Monoclonal Erk1 antibody, Anti-Erk1 antibody, MAPK3 antibody, mitogen-activated protein kinase 3 antibody, BOS_22892 antibody, Erk-1 antibody, ERK1 antibody, Ert2 antibody, Esrk1 antibody, extracellular signal-regulated kinase 1 antibody, extracellular signal-regulated kinase-1 antibody, extracellular signal-related kinase 1 antibody, fi06b09 antibody, HS44KDAP antibody, HUMKER1A antibody, insulin-stimulated MAP2 kinase antibody, MAPK1 antibody, MAPK 1 antibody, MAPK 3 antibody, MAP kinase 1 antibody, MAP kinase 3 antibody, MAP kinase-activated protein kinase 3 antibody, MAP kinase isoform p44 antibody, microtubule-associated protein 2 kinase antibody, mitogen-activated 3 (MAP kinase 3 antibody, mitogen-activated protein kinase 1 antibody, mitogen activated protein kinase 3 antibody, mitogen-activated protein kinase 3-like antibody, MNK1 antibody, Mtap2k antibody, p44 antibody, p44) antibody, p44erk1 antibody, p44-ERK1 antibody, p44mapk antibody, p44-MAPK antibody, p44 MAP kinase antibody, pp42/MAP kinase antibody, PRKM3 antibody, zERK1 antibody
Cross Reactivity Human, Rat
Applications ELISA, WB
Immunogen Erk1 antibody was raised in Mouse using a recombinant human protein purified from E.coli (His-Erk1) as the immunogen

Images

Western Blot analysis using Erk1 antibody (10R-8498)

Specifications

Host Mouse
Clone 33A5
Isotype IgG2a kappa
Method of Purification Erk1 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase, and activates it as well. Once actived, Raf phosphorylates other two kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in ERK 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1.

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Images

  • Western Blot analysis using Erk1 antibody (10R-8498) |

Availability: In stock

Price: $295.00
Size: 100 ul
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