ESPL1 antibody (10R-1708)

Mouse monoclonal ESPL1 antibody

Synonyms Monoclonal ESPL1 antibody, Anti-ESPL1 antibody, ESPL 1, ESPL-1, ESPL 1 antibody, ESPL-1 antibody, SEPARIN antibody, ESPL1, Extra spindle pole bodies homolog 1 antibody, FLJ46492 antibody, KIAA0165 antibody, ESP1 antibody
Specificity Human ESPL1
Cross Reactivity Human. Other species not studied
Applications Dot Blot
Immunogen ESPL1 antibody was raised in mouse using recombinant Human Extra Spindle Pole Bodies Homolog 1 (S. Cerevisiae) (Espl1)

Images

Western Blot analysis of immunized recombinant protein using ESPL1 antibody (10R-1708)

Specifications

Host Mouse
Clone 2329C1a
Isotype IgG1
Method of Purification ESPL1 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer ESPL1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

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Images

  • Western Blot analysis of immunized recombinant protein using ESPL1 antibody (10R-1708)

Availability: In stock

Price: $190.00
Size: 50 ug
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