FADD antibody (70R-10437)

Affinity purified rabbit polyclonal FADD antibody

Synonyms Polyclonal FADD antibody, Anti-FADD antibody, TNFRSF6-associated via death domain antibody, Fas
Cross Reactivity Human
Applications IHC, WB
Immunogen FADD antibody was raised in rabbit using the C terminal of FADD as the immunogen
Assay Information FADD Blocking Peptide, catalog no. 33R-1252, is also available for use as a blocking control in assays to test for specificity of this FADD antibody

Images

Western blot analysis using FADD antibody (70R-10437)

Recommended FADD Antibody Titration: 0.2-1 ug/ml

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-1 ug/ml

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.

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Images

  • Western blot analysis using FADD antibody (70R-10437) | Recommended FADD Antibody Titration: 0.2-1 ug/ml
  • Immunohistochemical staining using FADD antibody (70R-10437) | Human kidney

Availability: In stock

Price: $345.00
Size: 50 ug
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