FBLIM1 protein (His tag) (80R-2818)
Purified recombinant FBLIM1 protein (His tag)
|Synonyms||FBLIM1, FBLIM 1, FBLIM-1, FBLIM1, FBLIM 1 protein, FBLIM-1 protein, Filamin binding LIM 1 protein, CAL protein, FBLP-1 protein, FBLP1 protein, RP11-169K16.5 protein|
SDS-PAGE analysis of FBLIM1 protein (His tag) (80R-2818)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-373 aa: MGSSHHHHHH SSGLVPRGSH MGSMASKPEK RVASSVFITL APPRRDVAVA EEVRQAVCEA RRGRPWEAPA PMKTPEAGLA GRPSPWTTPG RAAATVPAAP MQLFNGGCPP PPPVLDGEDV LPDLDLLPPP PPPPPVLLPS EEEAPAPMGA SLIADLEQLH LSPPPPPPQA PAEGPSVQPG PLRPMEEELP PPPAEPVEKG ASTDICAFCH KTVSPRELAV EAMKRQYHAQ CFTCRTCRRQ LAGQSFYQKD GRPLCEPCYQ DTLERCGKCG EVVRDHIIRA LGQAFHPSCF TCVTCARCIG DESFALGSQN EVYCLDDFYR KFAPVCSICE NPIIPRDGKD AFKIECMGRN FHENCYRCED CRILLSVEPT DQGCYPLNNH LFCKPCHVKR SAAGCC|
|Purity||> 85% pure|
|Molecular Weight||43.1 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||Filamin binding LIM protein 1, also known as FBLIM1, serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. This protein is implicated in cell shape modulation (spreading) and motility. It may participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. FBLIM1 promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. Recombinant human FBLIM1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
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