FEN1 antibody (10R-1738)

Mouse monoclonal FEN1 antibody

Synonyms Monoclonal FEN1 antibody, Anti-FEN1 antibody, Flap structure-specific endonuclease 1 antibody, FEN 1, MF1 antibody, FEN 1 antibody, FEN-1, FEN-1 antibody, FEN-1 antibody, FEN1, RAD2 antibody
Specificity Human FEN1
Cross Reactivity Human. Other species not studied
Applications Dot Blot, ICC
Immunogen FEN1 antibody was raised in mouse using recombinant Human Flap Structure-Specific Endonuclease 1 (Fen1)

Images

Western blot analysis using FEN1 antibody (10R-1738)

Specifications

Host Mouse
Clone 2357C3a
Isotype IgG1
Method of Purification FEN1 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer FEN1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene.

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Images

  • Western blot analysis using FEN1 antibody (10R-1738) |

Availability: In stock

Price: $190.00
Size: 50 ug
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