FER antibody (10R-1848)

Mouse monoclonal FER antibody

Synonyms Monoclonal FER antibody, Anti-FER antibody, Fer tyrosine kinase antibody
Cross Reactivity Human, Mouse
Applications ELISA, IF, IHC, WB
Immunogen FER antibody was raised in Mouse using a purified recombinant fragment of human FER expressed in E. coli as the immunogen.

Images

Immunofluorescent staining using Western Blot analysis using FER antibody (10R-1848) (FER antibody)

Confocal immunofluorescence analysis of Hela cells using FER antibody (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

Specifications

Host Mouse
Clone 5D2C4
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance FER is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.

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Images

  • Immunofluorescent staining using Western Blot analysis using FER antibody (10R-1848) (FER antibody) | Confocal immunofluorescence analysis of Hela cells using FER antibody (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
  • Western Blot analysis using FER antibody (10R-1848) | Western Blot showing FER antibody used against NIH/3T3 (1), A549 (2) and SK-MEL-5 (3) cell lysate.
  • Immunohistochemical staining using FER antibody (10R-1848) | Immunohistochemical analysis of paraffin-embedded human kidney tissues using FER antibody.

Availability: In stock

Price: $375.00
Size: 100 ul
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