FGB antibody (10R-2162)
Mouse monoclonal FGB antibody
|Synonyms||Monoclonal FGB antibody, Anti-FGB antibody, Fibrinogen B beta polypeptide antibody, Fibrinogen beta chain antibody|
|Immunogen||FGB antibody was raised in Mouse using a purified recombinant fragment of human FGB (aa30-300) expressed in E. coli as the immunogen.|
Western Blot analysis using FGB antibody (10R-2162)
Western Blot showing FGB antibody used against human plasma (1).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||FGB is a gene found in humans and most other vertebrates with a similar system of blood coagulation. It is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.|
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