FGFR1 antibody (10R-1810)

Mouse monoclonal FGFR1 antibody

Synonyms Monoclonal FGFR1 antibody, Anti-FGFR1 antibody, FGFR-1, fms-related tyrosine kinase-2 antibody, Pfeiffer syndrome antibody, FGFR 1, FGFR 1 antibody, FGFR-1 antibody, basic fibroblast growth factor receptor 1 antibody, Fibroblast growth factor receptor 1 antibody, CD331 antibody, FGFR1
Cross Reactivity Human
Applications ELISA, WB
Immunogen FGFR1 antibody was raised in Mouse using purified recombinant extracellular fragment of human FGFR1(aa33-423) fused with hIgGFc tag expressed in HEK293 cells as the immunogen.

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Specifications

Host Mouse
Clone 3D4F7
Isotype IgG2b
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Product Uses: Monoclonal FGFR1 antibody specific for Human FGFR1 for use in ELISA and Western Blot. Biological Significance: FGFR1 a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). FGFR1 binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402.Tissue and Cell Localization: FGFR1 is integral to the plasma membrane, cytoplasmic membrane-bound vesicles, the cytosol and the nucleus. Cytogenetic Location: 8p11.23-p11.22. Molecular Location on chromosome 8: base pairs 38,411,137 to 38,468,833Implications in Disease:Defects in the FGFR1 gene have been widely reported in a number of disease conditions including several melonomas: Kallmann syndrome; rhave identified more than 40 FGFR1 gene mutations that cause Kallmann syndrome type 2, which is a condition characterized by delayed or absent puberty and an impaired sense of smell. 8p11 myeloproliferative; The FGFR1 gene is involved in a type of blood cancer called 8p11 myeloproliferative syndrome. This condition is characterized by an increased number of white blood cells (myeloproliferative disorder) and the development of lymphoma, a blood-related cancer that causes tumor formation in the lymph nodes. Osteoglophonic dysplasia ;Several mutations in the FGFR1 gene can cause a rare condition called osteoglophonic dysplasia. This condition is characterized by abnormal bone growth that leads to head and face (craniofacial) abnormalities and dwarfism. FGFR1 gene mutations that cause osteoglophonic dysplasia change single amino acids in the FGFR1 protein. The altered FGFR1 protein appears to cause prolonged signaling, which promotes premature fusion of bones in the skull and disrupts the regulation of bone growth in the arms and legs, leading to craniofacial abnormalities and shortened limbs. Pfeiffer syndrome: Similar to Osteoglophonic dysplasia. Cancers: Alterations in the activity (expression) of the FGFR1 gene are associated with certain cancers. The altered gene expression may enhance several cancer-related events such as cell division, cell movement, and the development of new blood vessels that nourish a growing tumor. The FGFR1 gene is abnormally active (overexpressed) in certain types of stomach and prostate cancers.Sequence Information: FGFR1 belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR1 consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain.Post-Translational Modifications: Autophosphorylated: Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Ubiquitinated: FGFR1 is rapidly ubiquitinated by NEDD4 after autophosphorylation, leading to internalization and lysosomal degradation. N-glycosylated in the endoplasmic reticulum: The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatusDatabase References: Entrez Gene: 2260 Human, Omim: 136350 Human, SwissProt: P11362 Human, Unigene: 264887 Human

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Images

  • Western Blot analysis using FGFR1 antibody (10R-1810) | Western Blot showing FGFR1 antibody used against extracellular domain of human FGFR1 (aa22-376).

Availability: In stock

Price: $345.00
Size: 100 ul
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