FGFR1OP protein (His tag) (80R-2305)
Purified recombinant Human FGFR1OP Protein (His tag)
|Synonyms||FGFROP-1, FGFROP 1, FGFROP 1 protein, FGFROP-1 protein, FOP protein, FGFR1OP|
Coomassie Blue stained SDS-PAGE of FGFR1OP protein (His tag) (80R-2305)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MGSSHHHHHH SSGLVPRGSH MGSHMAATAA AVVAEEDTEL RDLLVQTLEN SGVLNRIKAE LRAAVFLALE EQEKVENKTP LVNESLKKFL NTKDGRLVAS LVAEFLQFFN LDFTLAVFQP ETSTLQGLEG RENLARDLGI IEAEGTVGGP LLLEVIRRCQ QKEKGPTTGE GALDLSDVHS PPKSPEGKTS AQTTPSKKAN DEANQSDTSV SLSEPKSKSS LHLLSHETKI GSFLSNRTLD GKDKAGLCPD EDDMEGDSFF DDPIPKPEKT YGLRKEPRKQ AGSLASLSDA PPLKSGLSSL AGAPSLKDSE SKRGNTVLKD LKLISDKIGS LGLGTGEDDD YVDDFNSTSH RSEKSEISIG EEIEEDLSVE IDDINTSDKL DDLTQDLTVS QLSDVADYLE DVA|
|Purity||> 85% pure|
|Molecular Weight||43.5 kDa|
|Form & Buffer||Supplied in liquid form in 20 mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||FGFR1OP, also known as FGFR1 oncogene partner, belongs to the FGFR1OP family. This protein is a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Recombinant human FGFR1OP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
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