FHIT protein (His tag) (80R-1327)
Purified recombinant Human FHIT protein
|Synonyms||Fragile histidine triad protein protein, Bis (5'-adenosyl)-triphosphatase protein, FRA3B protein, FRA 3B protein, Fragile histidine triad gene protein, AP3A hydrolase fragile site 3p14.2 protein, Bis 5' adenosyl triphosphatase protein, Fragile histidine triad protein, Tumor suppressor protein., Fragile histidine triad protein AP3A hydrolase protein, Diadenosine 5' 5''' P1 P3 triphosphate hydrolase protein, Dinucleosidetriphosphatase protein, AP3Aase protein|
Coomassie Blue stained SDS-PAGE of FHIT protein (His tag) (80R-1327)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-147 amino acids: MSFRFGQHLI KPSVVFLKTE LSFALVNRKP VVPGHVLVCP LRPVERFHDL RPDEVADLFQ TTQRVGTVVE KHFHGTSLTF SMQDGPEAGQ TVKHVHVHVL PRKAGDFHRN DSIYEELQKH DKEDFPASWR SEEEMAAEAA ALRVYFQLEH HHHHH|
|Purity||> 95% pure|
|Molecular Weight||17.9 kDa(155aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||FHIT (fragile histidine triad) is an enzyme that cleaves adenosine 5' PPP 5' A to yield AMP and ADP. FHIT gene encompasses the common fragile site FRA3B on chromosome 3. Alterations and deletions of the FHIT gene are strongly linked to the genesis and establishment of human tumors of the lung, cervix, breast, colon, stomach and pancreas. In normal cells, FHIT may act as a tumor suppressor. This protein physically associates with ubiquitin conjugating enzyme 9. Recombinant human FHIT, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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