Fibronectin protein (30R-3224)

Purified recombinant Fibronectin protein

Synonyms Cold insoluble globulin protein, CIG protein, FN protein
Species Human
Protein Type Recombinant
Applications ELISA, SDS-PAGE, WB

Specifications

Residues Expression Region: 732-903aa; Ugl-Y2 chain fragment (23 kDa) with N terminal his tag.
Expression System E.coli
Purity > 90% pure
Molecular Weight 26 kDa
Tag/Conjugate His tag
Form & Buffer Expressed as an inclusion body supplied in liquid form in 6M guanidine hydrochloride and 20mM Tris buffer

Storage & Safety

Storage Store at 4 deg C in a working aliquot for 1 week. For long term storage, aliquot and freeze at -20 to -80 deg C, avoid repeat freeze/thaw cycles

General Information

Biological Significance Fibronectin fibrils exhibit salient elastic properties. Cells can stretch FN fibrils up to four-fold their relaxed length. The mechanical responses of FN are conferred by its multimodular structure composed predominantly of three different repeats termed FN-I, FN-II, and FN-III. Each of the two fibronectin subunits consists of 12 FN-I, 2 FN-II, and 15 to 17 FN-III modules, respectively. While each type I or type II module contains a couple of disulfide bonds that cross-link beta-strands of the module, type III modules do not contain any disulfide bond. Structurally, FN-III modules exhibit a seven-beta-stranded sandwich motif that has been found ubiquitously in many mammalian proteins.

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Availability: In stock

Price: $210.00
Size: 50 ug
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