Fibulin 5 antibody (10R-1884)
Mouse monoclonal Fibulin 5 antibody
|Synonyms||Monoclonal Fibulin 5 antibody, Anti-Fibulin 5 antibody, Fibulin -5 antibody, FBLN 5 antibody, FBLN-5 antibody, Fibulin 5, Fibulin 5 antibody, Fibulin -5, FBLN5 antibody, Fibulin 5|
|Immunogen||Fibulin 5 antibody was raised in Mouse using a purified recombinant fragment of Fibulin 5 expressed in E. coli as the immunogen.|
Western Blot analysis using Fibulin 5 antibody (10R-1884)
Western Blot showing fibulin5 antibody used against truncated fibulin5 recombinant protein (1) and Hela cell lysate (2).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Fibulin 5 is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.|
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