FUR protein (30R-1166)
Purified recombinant Human FUR protein
|Synonyms||DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport protein, Ferric uptake regulation protein protein, ECK0671 protein, FUR protein, Ferric uptake regulator protein, JW0669.|
Coomassie Blue stained SDS-PAGE of FUR protein (30R-1166)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-148 amino acids: MTDNNTALKK AGLKVTLPRL KILEVLQEPD NHHVSAEDLY KRLIDMGEEI GLATVYRVLN QFDDAGIVTR HNFEGGKSVF ELTQQHHHDH LICLDCGKVI EFSDDSIEAR QREIAAKHGI RLTNHSLYLY GHCAEGDCRE DEHAHEGK|
|Purity||> 95% pure|
|Molecular Weight||16.7 kDa (148aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 2mM CaCl2, and 100mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Fur (ferric uptake regulator) protein is a DNA-binding protein which regulates iron-responsive genes. Fur is a small, 17-kDa, global transcriptional repressor that in the presence of iron regulates functions as diverse as iron acquisition, oxidative stress, and virulence. In Escherichia coli, members of the Fur family regulate the expression of more than 100 genes that function in processes as varied as the biosynthesis and transport of siderophores, the expression of virulence factors, the alleviation of oxidative and NO-induced stress, and the inhibition of ferritin production through the expression of RyhB. Recombinant FUR was expressed in E. coli and purified by using conventional chromatography techniques.|
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