GADD45G protein (30R-1226)
Purified recombinant Human GADD45G protein
|Synonyms||GRP17, Growth arrest and DNA damage inducible gamma protein, DDIT2 protein, Growth arrest and DNA-damage-inducible gamma protein, GADD45G protein, Growth arrest and DNA-damage-inducible gamma protein, CR6 protein, Cytokine responsive protein CR6 protein|
Coomassie Blue stained SDS-PAGE of GADD45G protein (30R-1226)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-159 amino acids: MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER|
|Purity||> 95% pure|
|Molecular Weight||17.8 kDa (160 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl, pH 7.5.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||GADD45G is a member of GADD45 family (GADD45alpha, beta, and gamma) that are nuclear proteins with interact with various proteins implicated in stress responses and cell-cycle-related proteins. The function of GADD45 proteins is involved in growth-regulatory mechanisms and apoptosis. GADD45G protein responds to environmental stresses by mediating activation of p38/JNK pathway via MTK1/MEKK4 kinase and its transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. Recombinant GADD45G protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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