GALR2 Blocking Peptide (33R-10391)

A synthetic peptide for use as a blocking control in assays to test for specificity of GALR2 antibody, catalog no. 70R-10309

Synonyms GALR2 control peptide, GALR2 antibody Blocking Peptide, Anti-GALR2 Blocking Peptide, galanin receptor 2 Blocking Peptide, GALNR2 Blocking Peptide, MGC125983 Blocking Peptide, MGC125984 Blocking Peptide, GALR2, GALR-2, GALR 2, GALR-2 Blocking Peptide, GALR 2 Blocking Peptide
Protein Type Synthetic
Applications IHC, WB

Specifications

Residues RGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPK
Molecular Weight 43 kDa
Form & Buffer Lyophilized powder. Add 100ul of distilled water for a final peptide concentration is 1 mg/ml.

Storage & Safety

Storage Store at -20 deg C long term. Avoid repeat freeze-thaw cycles.

General Information

Biological Significance Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price: $130.00
Size: 100 ug
OR
Shipping
View Our Distributors