GIPC1 protein (His tag) (80R-1376)

Purified recombinant Human GIPC1 protein

Synonyms RGS19IP1 protein, GIPC 1, GIPC 1, GIPC protein, NIP protein, SYNECTIIN protein, SEMCAP protein, IIP 1 protein, GLUT1CBP protein, GIPC1, TIP 2 protein, TIP-2 protein, GIPC protein, GIPC-1, Hs.6454 protein, C19orf3 protein, Chromosome 19 open reading frame 3 protein, GIPC-1 protein, PDZ domain-containing protein GIPC1 protein, SYNECTIN protein, GIPC 1 protein, IIP-1 protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of GIPC1 protein (His tag) (80R-1376)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 1-333 amino acids: MGSSHHHHHH SSGLVPRGSH MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP PPALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIH LISVGDMIEA INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
Expression System E.coli
Purity > 95% pure
Molecular Weight 38.2 kDa (353aa) confirmed by MALDI-TOF
Tag/Conjugate His tag
Form & Buffer Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 1mM DTT, 0.1M NaCl, and 1mM EDTA.
Concentration 0.5 mg/ml

Storage & Safety

Storage Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance GIPC1 is a PDZ domain containing protein that interacts with RGS-GAIP and the viral oncoprotein TAX, which transactivates viral and cellular promoters through interactions with various transcription factors. GIPC specifically localizes to clusters of vesicles near the plasma membrane and participates in G protein-coupled signaling pathway involved in regulating Clathrin-coated vesicular trafficking. GIPC also associates with membrane bound Semaphorin F (M-SemF), which is involved in neuronal axon growth, and it appears to regulate the subcellular distribution of M-SemF in the brain. Recombinant human GIPC1 protein, fused to at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

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Images

  • Coomassie Blue stained SDS-PAGE of GIPC1 protein (His tag) (80R-1376) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: $395.00
Size: 50 ug
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