Glucose 6 Phosphate Isomerase antibody (10R-2136)
Mouse monoclonal Glucose 6 Phosphate Isomerase antibody
|Synonyms||Monoclonal Glucose 6 Phosphate Isomerase antibody, Anti-Glucose 6 Phosphate Isomerase antibody, GPI antibody, Phosphoglucose isomerase antibody, Glucose 6 Phosphate Isomerase,, -, antibody, - antibody|
|Applications||ELISA, IF, WB|
|Immunogen||Glucose 6 Phosphate Isomerase antibody was raised in Mouse using a purified recombinant fragment of human GPI expressed in E. coli as the immunogen.|
Immunofluorescent staining using Western Blot analysis using Glucose 6 Phosphate Isomerase antibody (10R-2136) (Glucose 6 Phosphate Isomerase antibody)
Confocal immunofluorescence analysis of L-02 cells using GPI antibody (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, IF: 1:200-1:1000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Glucose 6 Phosphate Isomerase belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways and it is an enzyme that catalyzes the conversion of glucose-6-phosphate into fructose 6-phosphate in the second step of glycolysis. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in GPI are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.|
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