GPI PLD antibody (10R-8439)

Mouse monoclonal GPI PLD antibody

Synonyms Monoclonal GPI PLD antibody, Anti-GPI PLD antibody, GPLD1 antibody, glycosylphosphatidylinositol specific phospholipase D1 antibody, BOS_21856 antibody, glycoprotein phospholipase D antibody, glycosylphosphatidylinositol phospholipase D antibody, glycosyl-phosphatidylinositol-specific phospholipase D antibody, GPIPLD antibody, GPI-PLD antibody, GPIPLDM antibody, GPI-specific phospholipase D antibody, phosphatidylinositol-glycan-specific phospholipase D antibody, phosphatidylinositol-glycan-specific phospholipase D-like antibody, PIGPLD antibody, PI-G PLD antibody, PIGPLD1 antibody, RP23-123C5.1 antibody
Cross Reactivity Human
Applications ELISA, IHC-P, WB
Immunogen GPI PLD antibody was raised in Mouse using a protein purified from Human plasma as the immunogen

Images

Western Blot analysis using GPI PLD antibody (10R-8439)

Specifications

Host Mouse
Clone 38A1
Isotype IgG1 kappa
Method of Purification GPI PLD antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:500, IHC-P

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance GPI-PLD (glycosylphosphati- dylinositol-specific phospholipase D), a 815-amino acid protein, is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPI-PLD in the serum. GPI-PLD is abundant in serum in which it associates with apolipoproteins AI and AIV. Increased serum GPI-PLD is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPI-PLD, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.

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Images

  • Western Blot analysis using GPI PLD antibody (10R-8439) |

Availability: In stock

Price: $295.00
Size: 100 ul
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