GRIN2B antibody (N-terminus) (70R-15026)

Rabbit polyclonal GRIN2B antibody (N-terminus)

Synonyms Polyclonal GRIN2B antibody, Anti-GRIN2B antibody, GRIN 2B antibody, GRIN-2B antibody, GRIN2B, Glutamate Receptor Ionotropic N-Methyl D-Aspartate 2B antibody, MGC142178 antibody, MGC142180 antibody, NMDAR2B antibody, NR2B antibody, hNR3 antibody
Applications IHC, WB

Images

Immunofluorescent staining using GRIN2B antibody (N-terminus) (70R-15026)

Immunofluorescent staining of 14 DIV rat cortical neurons showing NR2B in green andPSD95 in red

Specifications

Host Rabbit
Method of Purification GRIN2B antibody was purified by affinity chromatography
Form & Buffer Supplied in liquid form in 10 mM HEPES buffer (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:1000, IHC: 1:500

General Information

Biological Significance NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.

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Images

  • Immunofluorescent staining using GRIN2B antibody (N-terminus) (70R-15026) | Immunofluorescent staining of 14 DIV rat cortical neurons showing NR2B in green andPSD95 in red
  • Western Blot analysis using GRIN2B antibody (N-terminus) (70R-15026) | Western blot of 10 ug of rathippocampal lysate showing specific immunolabeling of ~180k NR2B subunit of the NMDA receptor

Availability: In stock

Price: $335.00
Size: 100 ul
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