GRIN2B antibody (Ser1166) (70R-15027)

Rabbit polyclonal GRIN2B antibody (Ser1166)

Synonyms Polyclonal GRIN2B antibody, Anti-GRIN2B antibody, GRIN 2B antibody, GRIN-2B antibody, GRIN2B, Glutamate Receptor Ionotropic N-Methyl D-Aspartate 2B antibody, MGC142178 antibody, MGC142180 antibody, NMDAR2B antibody, NR2B antibody, hNR3 antibody
Applications WB

Images

Western Blot analysis using GRIN2B antibody (Ser1166) (70R-15027)

Western blot of rat hippocampal lysate showing specific immunolabeling of ~180k NR2B subunit of the NMDAR phosphorylated at Ser1166 (Control)

Specifications

Host Rabbit
Method of Purification GRIN2B antibody was purified by affinity chromatography
Form & Buffer Supplied in liquid form in 10 mM HEPES buffer (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:250

General Information

Biological Significance NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD).

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Images

  • Western Blot analysis using GRIN2B antibody (Ser1166) (70R-15027) | Western blot of rat hippocampal lysate showing specific immunolabeling of ~180k NR2B subunit of the NMDAR phosphorylated at Ser1166 (Control)

Availability: In stock

Price: $335.00
Size: 100 ul
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