Hairy and Enhancer of Split 1 antibody (10R-8467)

Mouse monoclonal Hairy and Enhancer of Split 1 antibody

Synonyms Monoclonal Hairy and Enhancer of Split 1 antibody, Anti-Hairy and Enhancer of Split 1 antibody, Hes1 Hairy and enhancer of split 1 Hairy Enhancer of Split 1 Hairy Homolog Hairy like HHL HL HRY Transcription factor HES 1 antibody, Q8IXV0 antibody
Cross Reactivity Human, Mouse, Rat
Applications ELISA, IP, WB
Immunogen Hairy and Enhancer of Split 1 antibody was raised in Mouse using a His-tagged recombinant human Hes1 protein purified from E.coli as the immunogen

Images

Western Blot analysis using Hairy and Enhancer of Split 1 antibody (10R-8467)

Specifications

Host Mouse
Clone 7H11
Isotype IgG2b kappa
Method of Purification Hairy and Enhancer of Split 1 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:500-1000, IP: 1 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and beta-cells.

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Images

  • Western Blot analysis using Hairy and Enhancer of Split 1 antibody (10R-8467) |

Availability: In stock

Price: $295.00
Size: 100 ul
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