Harmonin protein (His tag) (80R-1160)
Purified recombinant Human Harmonin protein
|Synonyms||Harmonin protein, AIE75 protein, Usher syndrome type 1C protein protein, PDZ 73/NY CO 38 protein, PDZ 73 protein protein, AIE 75 protein, DFNB 18 protein, PDZ-45 protein, Usher syndrome 1C protein, PDZ-73 protein, PDZ 73 protein, DFNB18 protein, NY-CO-37 protein, Deafness autosomal recessive 18 protein, protein NY CO 38/NY CO 37 protein, PDZ45 protein, PDZ73 protein protein, USH1C protein, NY CO 38 protein, Autoimmune enteropathy related protein AIE 75 protein, Ush1cpst protein, Renal carcinoma protein NY REN 3 protein, USH 1C protein, NY-CO-38 protein, NY CO 37 protein, PDZ 45 protein, Autoimmune enteropathy related protein AIE75 protein, Usher syndrome 1C (autosomal recessive severe)., PDZ-73/NY-CO-38 protein, AIE-75 protein, PDZ73 protein|
Coomassie Blue stained SDS-PAGE of Harmonin protein (His tag) (80R-1160)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-533 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMDR KVAREFRHKV DFLIENDAEK DYLYDVLRMY HQTMDVAVLV GDLKLVINEP SRLPLFDAIR PLIPLKHQVE YDQLTPRRSR KLKEVRLDRL HPEGLGLSVR GGLEFGCGLF ISHLIKGGQA DSVGLQVGDE IVRINGYSIS SCTHEEVINL IRTKKTVSIK VRHIGLIPVK SSPDEPLTWQ YVDQFVSESG GVRGSLGSPG NRENKEKKVF ISLVGSRGLG CSISSGPIQK PGIFISHVKP GSLSAEVGLE IGDQIVEVNG VDFSNLDHKE GRELFMTDRE RLAEARQREL QRQELLMQKR LAMESNKILQ EQQEMERQRR KEIAQKAAEE NERYRKEMEQ IVEEEEKFKK QWEEDWGSKE QLLLPKTITA EVHPVPLRKP KYDQGVEPEL EPADDLDGGT EEQGEQDFRK YEEGFDPYSM FTPEQIMGKD VRLLRIKKEG SLDLALEGGV DSPIGKVVVS AVYERGAAER HGGIVKGDEI MAINGKIVTD YTLAEADAAL QKAWNQGGDW IDLVVAVCPP KEYDDELTFF|
|Purity||> 95% pure|
|Molecular Weight||64.6 kDa (570aa)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Harmonin, product encoded by USH1c gene, is a scaffold protein that functions in the assembly of Usher protein complexes. Usher syndrome type I caused by mutations in USH1C is an autosomal recessive sensory defect involving congenital profound sensorineural deafness, vestibular dysfunction, and blindness due to progressive retinitis pigmentosa. Hormonin has the ability to bind to many other proteins in cell membranes and coordinates their activities. Recombinant human Harmonin protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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