HAUSP antibody (10R-2219)

Mouse monoclonal HAUSP antibody

Synonyms Monoclonal HAUSP antibody, Anti-HAUSP antibody, USP7 antibody, Deubiquitinating enzyme 7 antibody, Ubiquitin specific peptidase 7 antibody, TEF1 antibody
Cross Reactivity Human
Applications ELISA, WB
Immunogen HAUSP antibody was raised in Mouse using a purified recombinant fragment of human HAUSP expressed in E. coli as the immunogen.

Images

Western Blot analysis using HAUSP antibody (10R-2219)

Western Blot showing HAUSP antibody used against MCF-7 (1) cell lysate.

Specifications

Host Mouse
Clone 5F11
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53. Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Images

  • Western Blot analysis using HAUSP antibody (10R-2219) | Western Blot showing HAUSP antibody used against MCF-7 (1) cell lysate.

Availability: In stock

Price: $345.00
Size: 100 ul
OR
Shipping
View Our Distributors