HAUSP antibody (10R-2219)
Mouse monoclonal HAUSP antibody
|Synonyms||Monoclonal HAUSP antibody, Anti-HAUSP antibody, USP7 antibody, Deubiquitinating enzyme 7 antibody, Ubiquitin specific peptidase 7 antibody, TEF1 antibody|
|Immunogen||HAUSP antibody was raised in Mouse using a purified recombinant fragment of human HAUSP expressed in E. coli as the immunogen.|
Western Blot analysis using HAUSP antibody (10R-2219)
Western Blot showing HAUSP antibody used against MCF-7 (1) cell lysate.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53. Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress.|
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