HCK antibody (10R-1973)

Mouse monoclonal HCK antibody

Synonyms Monoclonal HCK antibody, Anti-HCK antibody
Cross Reactivity Human
Applications ELISA, IHC, WB
Immunogen HCK antibody was raised in Mouse using a purified recombinant fragment of HCK expressed in E. coli as the immunogen.

Images

Immunohistochemical staining using HCK antibody (10R-1973)

Immunohistochemical analysis of paraffin-embedded human colon cancer (left) and ancreas cancer (right), showing cytoplasmic localization using HCK antibody with DAB staining.

Specifications

Host Mouse
Clone 3D12E10
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance HCK is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.

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Images

  • Immunohistochemical staining using HCK antibody (10R-1973) | Immunohistochemical analysis of paraffin-embedded human colon cancer (left) and ancreas cancer (right), showing cytoplasmic localization using HCK antibody with DAB staining.
  • Western Blot analysis using HCK antibody (10R-1973) | Western Blot showing HCK antibody used against truncated HCK recombinant protein (1) and full-length HCK-GFP transfected CHO-K1 cell lysate (2).

Availability: In stock

Price: $375.00
Size: 100 ul
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