HDAC3 antibody (10R-2004)

Mouse monoclonal HDAC3 antibody

Synonyms Monoclonal HDAC3 antibody, Anti-HDAC3 antibody, HD3 antibody, RPD3 antibody, HDAC-3 antibody, RPD3 2 antibody, HDAC 3, RPD3-2 antibody, HDAC3, HDAC-3, Histone Deacetylase 3 antibody, HDAC 3 antibody
Cross Reactivity Human
Applications ELISA, IHC, WB
Immunogen HDAC3 antibody was raised in Mouse using a purified recombinant fragment of HDAC3(aa224-428) expressed in E. coli as the immunogen.

Images

Immunohistochemical staining using HDAC3 antibody (10R-2004)

Immunohistochemical analysis of paraffin-embedded human esophagus cancer (left) and breast carcinoma tissue (right), showing nuclear localization with DAB staining using HDAC3 antibody.

Specifications

Host Mouse
Clone 3A7B5
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

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Images

  • Immunohistochemical staining using HDAC3 antibody (10R-2004) | Immunohistochemical analysis of paraffin-embedded human esophagus cancer (left) and breast carcinoma tissue (right), showing nuclear localization with DAB staining using HDAC3 antibody.
  • Western Blot analysis using HDAC3 antibody (10R-2004) | Western Blot showing HDAC3 antibody used against truncated Trx-HDAC3 recombinant protein (1), full length HDAC3-hIgGFc (aa1-428) transfected CHO-K1 cell lysate (2) and Hela cell lysate (3).

Availability: In stock

Price: $375.00
Size: 100 ul
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