Heparin cofactor II antibody (10R-8433)

Mouse monoclonal Heparin cofactor II antibody

Synonyms Monoclonal Heparin cofactor II antibody, Anti-Heparin cofactor II antibody, SERPIND1 antibody, serpin peptidase inhibitor antibody, clade D (heparin cofactor) antibody, member 1 antibody, BOS_16799 antibody, D22S673 antibody, EGK_02823 antibody, HC2 antibody, HCF2 antibody, HCII antibody, HC-II antibody, heparin cofactor 2 antibody, heparin cofactor II antibody, HLS2 antibody, leuserpin 2 antibody, leuserpin-2 antibody, LS2 antibody, PANDA_015968 antibody, protease inhibitor leuserpin-2 antibody, rls2var1 antibody, serine (or cysteine) peptidase inhibitor antibody, clade D antibody, member 1 antibody, serine (or cysteine) proteinase inhibitor antibody, clade D (heparin cofactor) antibody, member 1 antibody, serine (or cysteine) proteinase inhibitor antibody, clade D antibody, member 1 antibody, serpin D1 antibody, serpin peptidase inhibitor antibody, clade D antibody, member 1 antibody, THPH10 antibody
Cross Reactivity Human
Applications ELISA, IHC-P, WB
Immunogen Heparin cofactor II antibody was raised in Mouse using a protein purified from Human plasma as the immunogen

Images

Western Blot analysis using Heparin cofactor II antibody (10R-8433)

Specifications

Host Mouse
Clone 74E5
Isotype IgG2b kappa
Method of Purification Heparin cofactor II antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000, IHC-P

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Heparin cofactor II (HCII), a single chain glycoprotein with a MW of 65 kDa, is a serine protease inhibitor that is synthesized by the liver and circulates in plasma. Heparin cofactor II inhibits thrombin by formation of a stable bimolecular complex, but has no activity against other proteases involved in coagulation or fibrinolysis. The rate at which HCII inhibits thrombin increases more than 1000-fold in the presence of heparin, heparan sulfate, or dermatan sulfate. Heparin cofactor II is unique among serine protease inhibitors in its ability to be stimulated by dermatan sulfate, and it binds to a minor subpopulation of dermatan sulfate oligosaccharides. Turnover studies of labeled HCII in humans suggest that 40% of the protein equilibrates with an extravascular compartment, but the distribution of HCII in various tissues has not been thoroughly investigated. Heparin cofactor II has been detected in the intima of normal human arteries, and the ability of dermatan sulfate in the arterial wall to stimulate HCII is decreased in atherosclerotic lesions.

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Images

  • Western Blot analysis using Heparin cofactor II antibody (10R-8433) |

Availability: In stock

Price: $295.00
Size: 100 ul
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