HES2 protein (His tag) (80R-2966)
Purified recombinant IMPACT protein (His tag)
|Synonyms||Transcription factor HES-2 protein, bHLHb40 protein, hairy and enhancer of split 2 protein|
SDS-PAGE analysis of HES2 protein (His Tag) (80R-2966)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-173 aa: MGSSHHHHHH SSGLVPRGSH MGSMGLPRRA GDAAELRKSL KPLLEKRRRA RINQSLSQLK GLILPLLGRE NSNCSKLEKA DVLEMTVRFL QELPASSWPT AAPLPCDSYR EGYSACVARL ARVLPACRVL EPAVSARLLE HLWRRAASAT LDGGRAGDSS GPSAPAPAPA SAPEPASAPV PSPPSPPCGP GLWRPW|
|Purity||> 80% pure|
|Molecular Weight||20.9 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol|
Storage & Safety
|Storage||Store at 4 deg C for up to 2 weeks. For long term storage, aliquot and store at -20 deg C to -70 deg C. Avoid repeated freeze/thaw cycles|
|Biological Significance||Hairy and enhancer of split 2, also known as HES2, is a member of the HES family and contains one basic helix-loop-helix (bHLH) domain and one orange domain. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. Activation of Notch signaling pathway leads to activation of HES family genes through the interaction between Notch intracellular domain and RBPSUH (CSL). HES2 is expressed in a variety of adult and embryonic tissue.|
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