HINT1 protein (30R-1327)
Purified recombinant Human HINT1 protein
|Synonyms||PKCI1 protein, HINT 1 protein, Histidine triad nucleotide binding protein 1 protein, HINT1, Histidine triad nucleotide-binding protein 1 Adenosine 5' monophosphoramidase protein, Histidine triad nucleotide-binding protein 1 protein, PKCI 1 protein, HINT 1, HINT protein, HINT-1 protein, PKCI-1 protein, Protein kinase C interacting protein 1., PRKCNH1 protein, HINT 1 protein, HINT-1, Protein kinase C inhibitor 1 protein|
Coomassie Blue stained SDS-PAGE of HINT1 protein (30R-1327)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-126 amino acids: MADEIAKAQV ARPGGDTIFG KIIRKEIPAK IIFEDDRCLA FHDISPQAPT HFLVIPKKHI SQISVAEDDD ESLLGHLMIV GKKCAADLGL NKGYRMVVNE GSDGGQSVYH VHLHVLGGRQ MHWPPG|
|Purity||> 90% pure|
|Molecular Weight||13.8 kDa (126aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||HINT1, also known as Histidine triad nucleotide-binding protein 1, is a member of a superfamily named for a near C-terminal HXHXHXX motif (H:Histidine, X:a hydrophobic amino acid) positioned at the alpha-phosphate of nucleotide substrates. This protein hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2. Although it was originally thought to be a protein kinase C inhibitor and act as a haplod-insufficient tumor suppressor including spontaneous tumor formation in Hint+/- and Hint-/- , its actual physiologic function is not known. Recombinant human HINT1 protein was expressed in E. coli and purified by using conventional chromatography.|
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