HIV1 gp120 protein (30-AH86)

Purified full length recombinant HIV1 gp120 protein-IIIB strain

Synonyms HIV-1 gp120 protein, HIV 1 gp120, Glycoprotein 120 protein, SU protein, HIV-1 gp120 protein, gp120 protein, gp120 protein, HIV1 gp120, gp120 glycoprotein protein, HIV 1 gp120 protein, Envelope surface glycoprotein gp120 protein, Surface protein protein, Human Immunodeficiency Virus 1 protein, HIV 1 gp120 protein, HIV-1 gp120
Species Viral
Protein Type Recombinant
Applications ELISA

Specifications

Expression System CHO cells
Purity > 95% pure
Form & Buffer Supplied in PBS, with no preservatives.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user
Bioactivity This protein binds to human T-cell receptor CD4 in ELISA and Western ELISA as determined by CD4/gp120/Anti-gp120 mAb-peroxidase capture ELISA. This protein activates human T-Lymphocytes (CD4+, CD4-), in vitro, as measured by RNA synthesis during G0 to G1

Storage & Safety

Storage Aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles

General Information

Biological Significance Human immunodeficiency virus (HIV) is a lentivirus that causes acquired immunodeficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. The 120 in its name comes from its molecular weight of 120 kilodaltons. gp120 is essential for virus entry into cells as it plays a vital role in seeking out specific cell surface receptors for entry.

References
Add a Paper

Valeria Visalli, Carolina Muscoli, Iolanda Sacco, Francesca Sculco, Ernesto Palma, Nicola Costa, Carmela Colica, Domenicantonio Rotiroti, Vincenzo Mollace

N-acetylcysteine prevents HIV gp 120-related damage of human cultured astrocytes: correlation with glutamine synthase dysfunction

BMC Neuroscience

Issue: 8:106 DOI: 10.1186/1471-2202-8-106

Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA

The α7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response

Clin Transl Immunology

Volume: 4 Issue: December 2015 Page: e53 PMID: 6719799 DOI: 10.1038/cti.2015.31

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Availability: In stock

Price: $1,195.00
Size: 100 ug
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