HIV1 gp41 protein (30-039001)

Purified recombinant HIV1 gp41 protein

Synonyms gp41 antigen, HIV 1 gp41, HIV-1 gp41 protein, gp41 antigen, gp41 glycoprotein antigen, Glycoprotein 41 antigen, Envelope surface glycoprotein gp41 antigen, HIV-1 gp41 antigen, Human Immunodeficiency Virus 1 antigen, HIV1 gp41, Surface protein antigen, SU antigen, HIV 1 gp41 protein, HIV-1 gp41, HIV 1 gp41 antigen
Species Viral
Protein Type Recombinant
Applications ELISA, WB

Specifications

Expression System E.coli
Purity > 98% pure
Form & Buffer Supplied lyophilized from PBS buffer, with no preservatives added, reconstitute in sterile distilled water.

Usage & Assay Information

Usage Recommendations ELISA: 1:500-1:1,000, WB: 1:500-1:1,000

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance GP41 is a glycoprotein subunit that remains non-covalently-bound to gp120, and provides the second step by which HIV enters the cell. It is originally buried within the viral envelope, but, when gp120 binds to a CD4, gp120 changes its conformation, causing gp41 to become exposed, where it can assist in fusion with the host cell.

References
Add a Paper

David Opalka, Antonello Pessi, Elisabetta Bianchi, Gennaro Ciliberto, William Schleif, Michael McElhaugh, Renee Danzeisen, Romas Geleziunas, Michael Miller, Debra M. Eckert, David Bramhill, Joseph Joyce, James Cook, William Magilton, John Shiver, Emilio Emini, Mark T. Esser

Analysis of the HIV-1 gp41 specific immune response using a multiplexed antibody detection assay

Journal of Immunological Methods

Volume: 287 Issue: 1-2 Page: 49-65 DOI: 10.1016/j.jim.2004.01.016

Sean X. Du, Rebecca J. Idiart, Ellaine B. Mariano, Helen Chen, Peifeng Jiang, Li Xu, Kristin M. Ostrow, Terri Wrin, Pham Phung, James M. Binley, Christos J. Petropoulos, John A. Ballantyne, Robert G. Whalen

Effect of trimerization motifs on quaternary structure, antigenicity, and immunogenicity of a noncleavable HIV-1 gp140 envelope glycoprotein

Virology

Volume: 395 Issue: 1 Page: 33-44 DOI: 10.1016/j.virol.2009.07.042

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Availability: In stock

Price: $95.00
Size: 100 ug
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