HLADMB antibody (70R-14325)

Affinity purified Rabbit polyclonal HLADMB antibody

Synonyms Polyclonal HLADMB antibody, Anti-HLADMB antibody, Major histocompatibility complex class II DM beta antibody, HLADMB antibody, HLA-DM histocompatibility type beta chain antibody, D6S221E antibody, RING7 antibody, RING7 antibody
Applications IHC-P, WB
Immunogen HLADMB antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence in the middle regionof human HLA-DMB as the immunogen

Images

Immunohistochemical staining using HLADMB antibody (70R-14325)

Immunohistochemistry of paraffin-embedded section of Human Mammary, Cancer Tissue

Specifications

Host Rabbit
Isotype IgG
Method of Purification HLADMB antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance HLADMB is a protein that in humans is encoded by the HLA-DMB gene. The HLA-DMB gene is mapped on 6p21.32. HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. HLA-DMA and -DMB appear to encode subunits of a functional heterodimer that is critical in the pathway of class II antigen presentation.

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Images

  • <div><font face=Calibri size=2>Immunohistochemical staining using HLADMB antibody (70R-14325)</font></div>     | Immunohistochemistry of paraffin-embedded section of Human Mammary, Cancer Tissue
  • <div><font face=Calibri size=2>Western Blot analysis using HLADMB antibody (70R-14325)</font></div>     | Lane 1: Jurkat Cell Lysate, Lane 2: Jurkat Cell Lysate; Lane 3: RAJI Cell Lysate; Lane 4: HUT Cell Lysate

Availability: In stock

Price: $270.00
Size: 100 ug
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