HNE antibody (20R-HG007)

Goat polyclonal HNE antibody

Synonyms Polyclonal HNE antibody, Anti-HNE antibody, 4-Hydroxy Nonenal antibody
Cross Reactivity To be determined by end-user
Applications WB
Immunogen HNE antibody was raised in goat using 4-Hydroxynonenal protein as the immunogen.

Specifications

Host Goat
Isotype IgG
Form & Buffer Supplied as serum.

Usage & Assay Information

Usage Recommendations WB: >1:1,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

General Information

Biological Significance 4-Hydroxynonenal (HNE) is a highly reactive, cytotoxic aldehyde. HNE can efficiently react with sulfhydryl groups or histidine and lysine groups of proteins to form stable HNE-protein adducts, in addition to phospholipids and nucleic acids. It is through this HNE-modification of biomolecules that HNE is thought to exert its cytotoxic effects.

References
Add a Paper

Philip L. Davies, Nicola C. Maxwell, Sailesh Kotecha, O. Brad Spiller

Monoclonal anti-neutrophil elastase antibody characterisation: Ability to block function, detect free versus serpin-complexed enzyme and stain intracellular granule

Journal of Immunological Methods

Volume: 336 Issue: 2 Page: 175-182 DOI: 10.1016/j.jim.2008.04.010

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Availability: In stock

Price: $250.00
Size: 100 ug
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