HSD17B8 protein (His tag) (80R-1759)
Purified recombinant Human HSD17B8 protein
|Synonyms||HSDB8-17, HKE6 protein, HSDB8 17, HSD17B8, RING2 protein, HSDB8 17 protein, HSDB8-17 protein, FABGL protein, Estradiol 17-beta-dehydrogenase 8 protein|
Coomassie Blue stained SDS-PAGE of HSD17B8 protein (His tag) (80R-1759)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-261 amino acids: MGSSHHHHHH SSGLVPRGSH MASQLQNRLR SALALVTGAG SGIGRAVSVR LAGEGATVAA CDLDRAAAQE TVRLLGGPGS KEGPPRGNHA AFQADVSEAR AARCLLEQVQ ACFSRPPSVV VSCAGITQDE FLLHMSEDDW DKVIAVNLKG TFLVTQAAAQ ALVSNGCRGS IINISSIVGK VGNVGQTNYA ASKAGVIGLT QTAARELGRH GIRCNSVLPG FIATPMTQKV PQKVVDKITE MIPMGHLGDP EDVADVVAFL ASEDSGYITG TSVEVTGGLF M|
|Purity||> 95% pure|
|Molecular Weight||29.1 kDa (281aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 40% glycerol and 150mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||HSD17B8, also known as estradiol 17-beta-dehydrogenase 8, belongs to the short-chain dehydrogenases/reductases (SDR) family. In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. It may play a role in biosynthesis of fatty acids in mitochondria. Recombinant human HSD17B8 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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