HSP90B1 protein (His tag) (80R-1121)
Purified recombinant Human HSP90B1 protein
|Synonyms||gp96 homolog protein, GRP94 protein, HSP90B1 protein, Endothelial cell (HBMEC) glycoprotein protein, HSPB1-90 protein, Endoplasmin protein, Stress inducible tumor rejection protein GP96 protein, Glucose regulated protein 94kDa protein, Tumor rejection protein gp96., GP96 protein, HSPB1 90 protein, 94 kDa glucose-regulated protein protein, gp96 protein, HSPB1-90, Tumor rejection protein 1 protein, TRA1 protein, HSP90B1, GRP 9 protein, HSPB1 90, Heat shock protein 90 kDa beta member 1 protein, ECGP protein, 94 kDa glucose-regulated protein 94 kDa glucose regulated protein protein|
Coomassie Blue stained SDS-PAGE of HSP90B1 protein (His tag) (80R-1121)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||22-803 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMDDE VDVDGTVEED LGKSREGSRT DDEVVQREEE AIQLDGLNAS QIRELREKSE KFAFQAEVNR MMKLIINSLY KNKEIFLREL ISNASDALDK IRLISLTDEN ALSGNEELTV KIKCDKEKNL LHVTDTGVGM TREELVKNLG TIAKSGTSEF LNKMTEAQED GQSTSELIGQ FGVGFYSAFL VADKVIVTSK HNNDTQHIWE SDSNEFSVIA DPRGNTLGRG TTITLVLKEE ASDYLELDTI KNLVKKYSQF INFPIYVWSS KTETVEEPME EEEAAKEEKE ESDDEAAVEE EEEEKKPKTK KVEKTVWDWE LMNDIKPIWQ RPSKEVEEDE YKAFYKSFSK ESDDPMAYIH FTAEGEVTFK SILFVPTSAP RGLFDEYGSK KSDYIKLYVR RVFITDDFHD MMPKYLNFVK GVVDSDDLPL NVSRETLQQH KLLKVIRKKL VRKTLDMIKK IADDKYNDTF WKEFGTNIKL GVIEDHSNRT RLAKLLRFQS SHHPTDITSL DQYVERMKEK QDKIYFMAGS SRKEAESSPF VERLLKKGYE VIYLTEPVDE YCIQALPEFD GKRFQNVAKE GVKFDESEKT KESREAVEKE FEPLLNWMKD KALKDKIEKA VVSQRLTESP CALVASQYGW SGNMERIMKA QAYQTGKDIS TNYYASQKKT FEINPRHPLI RDMLRRIKED EDDKTVLDLA VVLFETATLR SGYLLPDTKA YGDRIERMLR LSLNIDPDAK VEEEPEEEPE ETAEDTTEDT EQDEDEEMDV GTDEEEETAK ESTAEKDEL|
|Purity||> 90% pure|
|Molecular Weight||94.4 kDa (819aa)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 1mM EDTA, 0.1M NaCl, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||GRP94, also known as Heat shock protein 90kDa beta, member 1 (HSP90B1), is an abundant resident endoplasmic reticulum (ER) lumenal stress protein which together with cytosolic Hsp90 belongs to the Hsp90 family of molecular chaperones. It plays an important role in maintaining protein homeostasis in the secretory pathway. Also, GRP94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I protein processing pathway of protein presentation cells. Recombinant human GRP94 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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