HSPA9 protein (His tag) (80R-1090)
Purified recombinant Human HSPA9 protein
|Synonyms||heat shock 70kDa protein 9B (mortalin-2) protein, Heat shock 70kDa protein 9 protein, HSPA9B protein, HSPA-9 protein, CSA protein, HSPA 9, HSPA9 protein, HSPA-9, PBP74 protein, HSPA9, HSPA 9 protein, GRP75 protein, Heat shock 70kDa protein 9 protein, Mortalin protein, heat shock 70kDa protein 9 (mortalin) protein, mot-2 protein, mthsp75|
Coomassie Blue stained SDS-PAGE of HSPA9 protein (His tag) (80R-1090)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||47-679 amino acids: MGSSHHHHHH SSGLVPRGSH MASEAIKGAV VGIDLGTTNS CVAVMEGKQA KVLENAEGAR TTPSVVAFTA DGERLVGMPA KRQAVTNPNN TFYATKRLIG RRYDDPEVQK DIKNVPFKIV RASNGDAWVE AHGKLYSPSQ IGAFVLMKMK ETAENYLGHT AKNAVITVPA YFNDSQRQAT KDAGQISGLN VLRVINEPTA AALAYGLDKS EDKVIAVYDL GGGTFDISIL EIQKGVFEVK STNGDTFLGG EDFDQALLRH IVKEFKRETG VDLTKDNMAL QRVREAAEKA KCELSSSVQT DINLPYLTMD SSGPKHLNMK LTRAQFEGIV TDLIRRTIAP CQKAMQDAEV SKSDIGEVIL VGGMTRMPKV QQTVQDLFGR APSKAVNPDE AVAIGAAIQG GVLAGDVTDV LLLDVTPLSL GIETLGGVFT KLINRNTTIP TKKSQVFSTA ADGQTQVEIK VCQGEREMAG DNKLLGQFTL IGIPPAPRGV PQIEVTFDID ANGIVHVSAK DKGTGREQQI VIQSSGGLSK DDIENMVKNA EKYAEEDRRK KERVEAVNMA EGIIHDTETK MEEFKDQLPA DECNKLKEEI SKMRELLARK DSETGENIRQ AASSLQQASL KLFEMAYKKM ASEREGSGSS GTGEQKEDQK EEKQ|
|Purity||> 95% pure|
|Molecular Weight||71 kDa (654 aa)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl, pH 8.0, containing 0.5mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||HSPA9 belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. HSPA9 was localized to chromosome 5, band q31, a region that is frequently deleted in myeloid leukemias and myelodysplasia (MDS), making it a candidate tumor suppressor gene, which is consistent with the biological function of its murine homologue. Also it inhibits nuclear translocation, transcriptional activation, and control of centrosome-duplication functions of p53. Recombinant human HSPA9 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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