HTATIP2 protein (His tag) (80R-1393)
Purified recombinant Human HTATIP2 protein
|Synonyms||HTATIP-2 protein, TIP-30, HTATIP 2, CC3 protein, HTATIP-2 protein, HTATIP2, HTATIP 2 protein, TIP30 protein, TIP 30 protein, HTATIP-2, SDR44U1 protein, CC-3 protein, Oxidoreductase HTATP2 protein, HTATIP 2 protein|
Coomassie Blue stained SDS-PAGE of HTATIP2 protein (His tag) (80R-1393)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-242 amino acids: MGSSHHHHHH SSGLVPRGSH MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWARGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP|
|Purity||> 95% pure|
|Molecular Weight||29.3 kDa (262aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||HTATIP2, also known as TIP30, is a member of the short-chain dehydrogenases/reductases (SDR) family. It acts as a tumor suppressor participating in metabolic suppression, inhibition of angiogenesis and induces the expression of apoptosis related genes Bad and Siva. HTATIP2 interacts with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II). Defects in This protein are associated with hepatocellular carcinomas and apoptotic resistant tumor cells, suggesting a potential use for HTATIP2 in antitumor therapy. Recombinant human HTATIP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques|
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