Human IgA antibody (10R-8448)

Mouse monoclonal Human IgA antibody

Synonyms Monoclonal Human IgA antibody, Anti-Human IgA antibody, Human IgA antibody, A2m marker antibody, FLJ14473 antibody, FLJ35065 antibody, FLJ35500 antibody, FLJ36402 antibody, FLJ39698 antibody, FLJ40001 antibody, FLJ41548 antibody, FLJ41552 antibody, FLJ41789 antibody, FLJ43248 antibody, FLJ43594 antibody, FLJ44293 antibody,FLJ46028 antibody, FLJ46621 antibody, FLJ46724 antibody, FLJ46811 antibody, FLJ46824 antibody, Ig alpha 1 chain C region antibody, Ig alpha 2 chain C region antibody, IgA1 antibody, Igh2 antibody, IGHA 1 antibody, IGHA 2 antibody, IGHA1 antibody, IGHA2 antibody, Immunoglobulin alpha 1 antibody, Immunoglobulin Am1 antibody, Immunoglobulin Am2 antibody, Immunoglobulin heavy chain 2 (serum IgA) antibody, Immunoglobulin heavy constant alpha 1 antibody, Immunoglobulin heavy constant alpha 2 antibody, MGC102857 antibody, P01877 antibody, P01876 antibody
Cross Reactivity Human
Applications ELISA, IHC-P, IP, WB
Immunogen Human IgA antibody was raised in Mouse using a protein purified from Human plasma as the immunogen

Images

Western Blot analysis using Human IgA antibody (10R-8448)

Specifications

Host Mouse
Clone 47C12
Isotype IgG1 kappa
Method of Purification Human IgA antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000, IP: 0.5 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance IgA represents about 15% to 20% of immunoglobulins in the blood, although it is primarily secreted across the mucosal tract into the stomach and intestines. This prevents microbes from binding to epithelial cells in the digestive and respiratory tracts. It does not activate complement, and opsonises only weakly. It exists in two forms, IgA1 (90%) and IgA2 (10%) that differ in the structure. IgA1 is composed like other proteins, however in IgA2 the heavy and light chains are not linked with disulfide but with noncovalent bonds. IgA1 is found in serum and made by bone marrow B cells, however IgA2 is made by B cells located in the mucosae and has been found to secrete into, colostrum, maternal milk, tears and saliva. The IgA found in secretions represent dimeric form, linked by two additional chains, the J chain and the secretory chain. Decreased or absent IgA, termed selective IgA deficiency, can be a clinically significant immunodeficiency.

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Images

  • Western Blot analysis using Human IgA antibody (10R-8448) |

Availability: In stock

Price: $295.00
Size: 100 ul
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