Human IgG antibody (10R-8446)

Mouse monoclonal Human IgG antibody

Synonyms Monoclonal Human IgG antibody, Anti-Human IgG antibody, Human IgG antibody, DKFZp686H11213 antibody, DKFZp686I04196 antibody, FLJ39988 antibody, FLJ40036 antibody, FLJ40253 antibody, FLJ40587 antibody, FLJ40789 antibody, FLJ40834 antibody, G1m marker antibody, G2m marker antibody, G3m marker antibody, G4m marker antibody, HDC antibody, Heavy chain disease protein antibody, Human immunglobulin G antibody, Ig gamma 1 chain C region antibody, Ig gamma 2 chain C region antibody, Ig gamma 3 chain C region antibody, Ig gamma 4 chain C region antibody, IGHG 1 antibody, IGHG 2 antibody, IGHG 3 antibody, IGHG 4 antibody, IGHG1 antibody, IGHG2 antibody, IGHG3 antibody, IGHG4 antibody, Immunoglobulin heavy constant gamma 1 antibody, Immunoglobulin heavy constant gamma 2 antibody, Immunoglobulin heavy constant gamma 3 antibody, Immunoglobulin heavy constant gamma 4 antibody, MGC117419 antibody, MGC45809 antibody, P01857 antibody, P01859 antibody, P01860 antibody, P01861 antibody
Cross Reactivity Human
Applications ELISA, IHC-P, IP, WB
Immunogen Human IgG antibody was raised in Mouse using a protein purified from Human plasma as the immunogen

Images

Western Blot analysis using Human IgG antibody (10R-8446)

Specifications

Host Mouse
Clone 3E8
Isotype IgG1 kappa
Method of Purification Human IgG antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000, IP: 0.5 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Immunoglobulin G (IgG) is a monomeric immunoglobulin, built of two heavy chains gamma and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids. This is the only isotype that can pass through the placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%). 1) IgG1, IgG3 and IgG4 cross the placenta easily. 2) IgG3 is the most effective complement activator and IgG4 does not activate complement. 3) IgG1 and IgG3 bind with high affinity to Fc receptors on phagocytic cells. IgG4 has intermediate affinity and IgG2 affinity is extremely low.

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Images

  • Western Blot analysis using Human IgG antibody (10R-8446) |

Availability: In stock

Price: $295.00
Size: 100 ul
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