Human IgG Fc (31R-1074)

Purified native IgG Fc protein

Synonyms Fragment crystallizable region protein
Species Human
Protein Type Native
Applications ELISA, SDS-PAGE, WB

Images

SDS-PAGE analysis of Human IgG Fc (31R-1074)

Specifications

Source Human serum IgG digested with papain
Purity > 90% pure
Form & Buffer Supplied in liquid form in 20mM Tris-HCl, pH 8.0 with 50% glycerol

Storage & Safety

Storage Store at 4 deg C in a working aliquot for 1 week. For long term storage, aliquot and freeze at -20 to -80 deg C, avoid repeat freeze/thaw cycles

General Information

Biological Significance The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. InIgG, IgA and IgD antibody isotypes, the Fc region is composed of two identical protein fragments, derived from the second and third constant domains of the antibody's two heavy chains; IgM and IgE Fc regions contain three heavy chain constant domains (CH domains 2–4) in each polypeptide chain. The Fc regions of IgGs bear a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. In addition, small amounts of these N-glycans also bear bisecting GlcNAc and alpha-2,6 linked sialic acid residues. The other part of an antibody, called the Fab region, contains variable sections that define the specific target that the antibody can bind. By contrast, the Fc region of all antibodies in a class are the same for each species; they are constant rather than variable. The Fc region is, therefore, sometimes incorrectly termed the "fragment constant region".

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Images

  • SDS-PAGE analysis of Human IgG Fc (31R-1074)

Availability: In stock

Price: $325.00
Size: 1 mg
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