Human IgM antibody (10R-8447)

Mouse monoclonal Human IgM antibody

Synonyms Monoclonal Human IgM antibody, Anti-Human IgM antibody, Human IgM antibody, Constant region of heavy chain of IgM antibody, Ig mu chain C region antibody, IGHM antibody, Immunoglobin heavy constant mu antibody, Immunoglobulin mu antibody, Immunoglobulin mu chain antibody, Imunoglobulin heavy chain antibody, MU antibody, VH antibody, P01871 antibody
Cross Reactivity Human
Applications ELISA, IHC-P, IP, WB
Immunogen Human IgM antibody was raised in Mouse using a protein purified from Human plasma as the immunogen

Images

Western Blot analysis using Human IgM antibody (10R-8447)

Specifications

Host Mouse
Clone 13A11
Isotype IgG1 lambda
Method of Purification Human IgM antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000, IP: 0.5 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Immunoglobulin M (IgM) forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, normally as a pentamer and the J chain is attached to most pentamers. It has a large molecular mass of approximately 900 kD. Due to its polymeric nature, IgM possesses high avidity, and is particularly effective at complement activation. It is sometimes called a "natural antibody", but it is likely that the antibodies arise due to sensitization in the very young to antigens that are naturally occurring in nature. IgM is the first immunoglobulin expressed by mature B cells. IgM antibodies appear early in the course of an infection and usually do not reappear after further exposure. IgM antibodies do not pass across the human placenta. These two biological properties of IgM make it useful in the diagnosis of infectious diseases. Demonstrating IgM antibodies in patients serum indicates recent or in serum from a neonate intrauterine infection such as congenital rubella.

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Images

  • Western Blot analysis using Human IgM antibody (10R-8447) |

Availability: In stock

Price: $295.00
Size: 100 ul
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