Human IL1 beta ELISA kit (55R-1605)

ELISA kit for the detection of IL1 beta in the research laboratory

Synonyms Human Interleukin 1 beta ELISA kit, IL1-beta ELISA kit
Applications ELISA
Assay Information Sensitivity: 1.56 pg/ml-100 pg/ml

Images

ELISA assay using Human IL1 beta ELISA kit (55R-1605)

Graph showing ELISA absorbance curve (O.D.) of Human IL1beta (pg/ml)

Specifications

Form & Buffer This Kit contains: Lyophilized recombinant human IL-1

Storage & Safety

Storage Store at 4 deg C for short term storage (4 months) or -20 deg C for long term storage (8 months)

General Information

Biological Significance Interleukin 1 (IL1), originally described in 1972 as lymphocyte activating factor (LAF) for its effects on thymocytes, is a polypeptide cytokine with two molecular forms. Both forms appear to mediate identical ranges of biological activity which include synthesis of the acute phase proteins by hepatocytes, chemotaxis of polymorphonucleocytes, and release of polymorphonucleocytes from blood and bone marrow. The two distinct molecular forms of IL1 are thought to be derived from two genes. After transcription, a 31 kDa precursor polypeptide is cleaved to give rise to mostly cell membrane associated IL1 and secreted IL1. Both have the same molecular weight of 15 kDa but have different isoelectric points of 5 and 7, respectively. Low levels of IL1 beta have been reported in normal serum. It is thought that IL1 genes are induced to respond to tissue damage or in infection. Elevated levels have been reported in a number of infectious disease conditions and in noninfectious inflammatory conditions such as Crohn?s disease. In addition to elevated serum levels, IL1 has been found in synovial fluids of patients with rheumatoid arthritis and incerebrospinal fluid after neurological inflammation or insult. At the other end of the spectrum, low levels of IL1 have been found in malnutrition and advanced neoplasia suggesting perhaps a complex immunological and physiological regulatory role for this cytokine.

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  • <div><font face=Calibri size=2>ELISA assay using Human IL1 beta ELISA kit (55R-1605)</font></div>     | Graph showing ELISA absorbance curve (O.D.) of Human IL1beta (pg/ml)

Availability: In stock

Price: $285.00
Size: 1 kit
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