Human Leptin Receptor ELISA kit (55R-1637)

ELISA kit for the detection of Leptin Receptor in the research laboratory

Synonyms Human Leptin Receptor ELISA kit
Applications ELISA
Assay Information Sensitivity: 156 pg/ml-10,000 pg/ml

Images

ELISA assay using Human Leptin Receptor ELISA kit (55R-1637)

Graph showing ELISA absorbance curve (O.D.) of Human Leptin receptor (pg/ml)

Specifications

Form & Buffer This Kit contains: Lyophilized recombinant human LeptinR standard: 100ng/tube

Storage & Safety

Storage Store at 4 deg C for short term storage (4 months) or -20 deg C for long term storage (8 months)

General Information

Biological Significance Leptin receptor (OBR) was identified as a leptin binding protein (Leptin, the product of the ob gene, is a single chain 16 kDa protein consisting of 146 amino acid residues). OBR was found to be a member of the class I cytokine receptor family with a large extracellular domain comprising 816 amino acid residues. Leptin receptor exists in multiple forms with a common extracellular domain and a variable length cytoplasmatic portion. Alternate splicing from a single gene derives the six isoforms of the Leptin receptor. The soluble form of the Leptin receptor, OBR contains no intracellular motifs or transmembrane residues, thus it consists entirely of the extracellular ligandbinding domain of the receptor.Long forms of OBR transcripts were reported to be expressed predominantly in regions of the hypothalamus which provides evidence that Leptin receptor is important in body weight regulation. Expression of short forms of OBR transcripts have been found in multiple tissues, including the choroid plexus, lung, kidney, and primitive hematopoietic cell populations. Leptin receptor may act as a negative regulator of Leptin activity and it may maintain a pool of available bio-active Leptin by binding and delaying its clearance from circulation.

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Images

  • <div><font face=Calibri size=2>ELISA assay using Human Leptin Receptor ELISA kit (55R-1637)</font></div>     | Graph showing ELISA absorbance curve (O.D.) of Human Leptin receptor (pg/ml)

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Price: $350.00
Size: 1 kit
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